BackgroundSkin Cutaneous Melanoma (SKCM) incidence is continually increasing, with chemotherapy and immunotherapy being among the most common cancer treatment modalities.This study aims to identify novel biomarkers for chemotherapy and immunotherapy response in SKCM and explore their association with oxidative stress.MethodsUtilizing TCGA-SKCM RNA-
Can nano-hydroxyapatite permeate the oral mucosa? A histological study using three-dimensional tissue models.
Nano-hydroxyapatite is used in oral care products worldwide.But there is little evidence yet whether nano-hydroxyapatite can enter systemic tissues via the oral epithelium.We investigated histologically the ability of two types of nano-hydroxyapatite, SKM-1 and Mi-HAP, to permeate oral epithelium both with and without a stratum corneum, using two t
The complete mitochondrial genome of the firefly, Curtos costipennis (Coleoptera: Lampyridae)
We report the complete mitochondrial genome of firefly, Curtos costipennis.The circular genome of 16,626 bp and has a base composition of A (44.44%), C (11.36%), G (7.61%), and T (36.58%).Our sequence is similar to other Metazoa, which contains 13 protein-coding genes.All 13 protein-coding genes Resines UV were initiated by the ATN (ATT, ATA, and A
The impact of Planned Special Events (PSEs) on urban traffic congestion
The transport infrastructure of many cities has not been able to keep up with the pace of growth in the motorization rate or to counteract the intensification of urban traffic.Rising in traffic congestion in cities not only impacts the productivity costing billions but also responsible for more than 40% of all CO2 emissions which results in global
Hypothesis and Theory: A Two-Process Model of Torpor-Arousal Regulation in Hibernators
Hibernating mammals drastically lower their metabolic rate (MR) and body temperature (Tb) for up to several weeks, but regularly rewarm and stay euthermic for brief periods.It has been hypothesized that the necessity for rewarming is due to the accumulation or depletion of metabolites, or the accrual of cellular damage that can be eliminated only i