Experimentally validated oxidative stress -associated prognostic signatures describe the immune landscape and predict the drug response and prognosis of SKCM

BackgroundSkin Cutaneous Melanoma (SKCM) incidence is continually increasing, with chemotherapy and immunotherapy being among the most common cancer treatment modalities.This study aims to identify novel biomarkers for chemotherapy and immunotherapy response in SKCM and explore their association with oxidative stress.MethodsUtilizing TCGA-SKCM RNA-

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Can nano-hydroxyapatite permeate the oral mucosa? A histological study using three-dimensional tissue models.

Nano-hydroxyapatite is used in oral care products worldwide.But there is little evidence yet whether nano-hydroxyapatite can enter systemic tissues via the oral epithelium.We investigated histologically the ability of two types of nano-hydroxyapatite, SKM-1 and Mi-HAP, to permeate oral epithelium both with and without a stratum corneum, using two t

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